T-bet, also known as T-box transcription factor T-bet, is considered to be a ‘master regulator’ of Th1 lymphoid development controlling the production of the cytokine IFN-γ. T-bet is widely expressed in hematopoietic cells including stem cells, NK cells, B cells, and T cells. T-bet is critical for the control of microbial pathogens, and knockout animals show multiple physiologic and inflammatory features characteristic of asthma. T-bet expression is optimally observed after IL-12 stimulation and can be suppressed by addition of the Th2 cytokine IL-4 or neutralization of IL-12. PRODUCT DETAILS Clone: 4B10 Antibody Type: Monoclonal Reactivity: Human, Mouse Format: BV605 Host: Mouse Isotype: IgG1, κ Applications: ICFC – Quality tested Regulatory Status: RUO Data Sheets: TDS | SDS Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
